منابع مشابه
Revelations from a bicistronic calcium channel gene
The voltage-gated calcium channel (VGCC), CACNA1A, is associated with several neurological disorders, including familial hemiplegic migraine, episodic ataxia type 2, epilepsy, and spinocerebellar ataxia type 6 (SCA6). CACNA1A encodes the Cav2.1 (α1A) subunit, the main pore-forming subunit of the P/Qtype VGCC, responsible for the Ca currents that mediate transmitter release in many CNS synapses....
متن کاملStructural revelations of the human proton channel.
The voltage-gated proton channel, HV1, is notoriously unique among ion channels (1), and plays key roles in the health and disease of diverse tissues and species (2). Li et al. (3) combine biochemical, computational, and electron paramagnetic resonance (EPR) spectroscopic approaches to shed light on structural aspects of the human proton channel, hHV1. Their results advance the field in several...
متن کاملTransmembrane topology of a CLC chloride channel.
CLC chloride channels form a large and conserved gene family unrelated to other channel proteins. Knowledge of the transmembrane topology of these channels is important for understanding the effects of mutations found in human myotonia and inherited hypercalciuric kidney stone diseases and for the interpretation of structure-function studies. We now systematically study the topology of human Cl...
متن کاملeffect of sub-grid scales on large eddy simulation of particle deposition in a turbulent channel flow
چکیده ندارد.
15 صفحه اولA novel chloride channel localizes to Caenorhabditis elegans spermatids and chloride channel blockers induce spermatid differentiation.
Caenorhabditis elegans spermatogenesis is especially suited for studies of nonrandom cytoplasmic segregation during cellular differentiation. Spermatocytes separate from an anuclear cytoplasmic core and undergo two sequential divisions. During the second division, intracellular organelles segregate specifically to spermatids as they bud from an anuclear residual body. We have applied patch-clam...
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ژورنال
عنوان ژورنال: Nature
سال: 1990
ISSN: 0028-0836,1476-4687
DOI: 10.1038/348489a0